Glycosyl-nucleoside-lipid based supramolecular assembly as a nanostructured material with nucleic acid delivery capabilities

Chem Commun (Camb). 2009 Sep 14:(34):5127-9. doi: 10.1039/b906212b. Epub 2009 Jul 17.

Abstract

A glycosyl-nucleoside-lipid self-assembles to give highly organized structures such as fibers and nanotubes, which can stabilize hydrogels; carbohydrate moieties provide a suitable environment to deliver nucleic acids into human cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Carriers / chemistry
  • Drug Delivery Systems*
  • Glucose / chemistry*
  • Hepatocytes / chemistry
  • Humans
  • Hydrogels / chemistry
  • Lipids / chemistry*
  • Macromolecular Substances / chemistry
  • Materials Testing
  • Molecular Structure
  • Nanostructures / chemistry*
  • Oligonucleotides / chemistry*
  • Particle Size
  • Surface Properties
  • Transfection

Substances

  • Drug Carriers
  • Hydrogels
  • Lipids
  • Macromolecular Substances
  • Oligonucleotides
  • Glucose