Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction

Chem Commun (Camb). 2009 Sep 14:(34):5091-3. doi: 10.1039/b908207g. Epub 2009 Jun 24.

Abstract

Oligobenzamide inhibitors of the p53-hDM2 protein-protein interaction are described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzamides / chemistry
  • Benzamides / pharmacology*
  • Binding Sites
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Protein Binding / drug effects
  • Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-mdm2 / metabolism
  • Structure-Activity Relationship
  • Tumor Suppressor Protein p53 / antagonists & inhibitors*
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Benzamides
  • Enzyme Inhibitors
  • Tumor Suppressor Protein p53
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2