The solubility of chlorhexidine is highly dependent on the salt present in solution. The aim of present research was evaluation of the effect of two polymers: polyacrylic acid and methylcellulose on the pH of resulting preparation, containing chlorhexidine. Also the solubility aspect was considered in the discussion, as an helpful issue in development in drug form technology. Preparations of chlorhexidine with methylcellulose are characterized by high pH in the range between 9,70-9,98 depending on the temperature of measurements. For preparations of chlorhexidine and polyacrylic acid pH of 5,31-5,72 was evaluated, which was near the physiological values of skin pH. The polyacrylic acid acts as a buffer and enables maintaining of pH near to physiological values. As the connection between polyacrylic acid and chlorhexidine seems to be strong, respective assessments of antimicrobial activity should be performed, to evaluate the applicative value of the preparations.