Abstract
A new crystal structure of an anti–HIV-1 envelope antibody bound to an envelope–receptor complex shows the antibody binding both the HIV-1 envelope and the CD4 receptor, raising the question of what the role of antibody autoreactivity in host responses to HIV-1 may be.
MeSH terms
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AIDS Vaccines / immunology
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Autoantibodies / immunology*
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CD4 Antigens / immunology
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HIV Antibodies / chemistry*
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HIV Antibodies / immunology*
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HIV Infections / immunology*
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HIV-1 / immunology*
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Host-Pathogen Interactions
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Humans
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Viral Envelope Proteins / immunology
Substances
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AIDS Vaccines
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Autoantibodies
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CD4 Antigens
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HIV Antibodies
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Viral Envelope Proteins