The asymmetric unit of the title complex, [CdCl(2)(C(14)H(12)N(4)O(2)S)(2)](n), consists of one Cd(II) ion located on the crystallographic inversion centre, one 4-benzoyl-1-isonicotinoylthiosemicarbazide ligand and one chloride ligand. The central Cd(II) ion adopts a distorted octahedral coordination geometry formed by two pyridyl N atoms of two ligands, two S atoms of two other ligands and two chloride ligands. The thiosemicarbazide ligands act as bridges, linking the metal ions into a two-dimensional layered structure parallel to the bc plane. Intermolecular N-H...O hydrogen bonds and C-H...pi interactions exist between adjacent layers.