Abstract
Two complementary sets of conditions for radical additions of thiols to terminal ynamides are described. The use of 1 equiv of thiol affords the cis-beta-thioenamide adducts in rapid fashion (10 min) and good dr, whereas employing excess thiol and longer reaction times favors the trans products.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry*
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Amides / chemistry
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Catalysis
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Molecular Structure
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Peptides, Cyclic / chemical synthesis*
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Peptides, Cyclic / chemistry
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Stereoisomerism
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Sulfhydryl Compounds / chemistry*
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Thioamides / chemical synthesis*
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Thioamides / chemistry
Substances
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Alkynes
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Amides
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Peptides, Cyclic
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Sulfhydryl Compounds
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Thioamides
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thioviridamide