We studied clinical parameters and characteristics of the nonspecific brain activity, reflecting interhemispheric interactions, in patients with discirculatory encephalopathy (DEP) who had arterial hypertension. Forty-six patients with DEP (25 - with DEP, II stage, 21 - with DEP, III stage) without epileptic changes on EEG were examined. The control group included 44 healthy people. EEG was assessed using the visual analysis according to E.A. Zhimunskaya, spectral analysis programs with mapping, degree of interhemispheric asymmetry of brain biopotential power. The more severe was the disease, the lower was the power of brain bioelectric activity. Variants of functioning of nonspecific brain activity in different stages of DEP were found in the study of the degree of interhemispheric asymmetry of brain biopotential power. The activity of synchronization areas of the brain dominated in the initial DEP stages, and that of desynchronization areas - in the later stages.