Structural and DNA cleavage of sugar-derived Schiff base ligands and their dinuclear Cu(II) complexes

Subbiah Nagarajan; Anupa Kumbhar; Babu Varghese; Thangamuthu Mohan Das

doi:10.1016/j.carres.2010.01.010

Structural and DNA cleavage of sugar-derived Schiff base ligands and their dinuclear Cu(II) complexes

Carbohydr Res. 2010 Jun 16;345(9):1077-83. doi: 10.1016/j.carres.2010.01.010. Epub 2010 Jan 28.

Authors

Subbiah Nagarajan¹, Anupa Kumbhar, Babu Varghese, Thangamuthu Mohan Das

Affiliation

¹ Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India.

PMID: 20435298
DOI: 10.1016/j.carres.2010.01.010

Abstract

Neutral dinuclear Cu(II) complexes of Schiff base ligands derived from D-glucose have been synthesized and structurally characterized. These complexes were evaluated for their interaction with DNA, and DNA cleavage was observed even in the presence of radical inhibitors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrates / chemistry*
Copper / chemistry*
Crystallography, X-Ray
DNA / metabolism*
Glycosylation
Ligands
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry*
Organometallic Compounds / metabolism*
Schiff Bases / chemistry*

Substances

Carbohydrates
Ligands
Organometallic Compounds
Schiff Bases
Copper
DNA