Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro

Elisabeth Maier; Katharina Kurz; Marcel Jenny; Harald Schennach; Florian Ueberall; Dietmar Fuchs

doi:10.1016/j.fct.2010.04.042

Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro

Food Chem Toxicol. 2010 Jul;48(7):1950-6. doi: 10.1016/j.fct.2010.04.042. Epub 2010 May 11.

Authors

Elisabeth Maier¹, Katharina Kurz, Marcel Jenny, Harald Schennach, Florian Ueberall, Dietmar Fuchs

Affiliation

¹ Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.

PMID: 20435078
DOI: 10.1016/j.fct.2010.04.042

Abstract

Food preservatives sodium benzoate and propionic acid and colorant curcumin are demonstrated to suppress in a dose-dependent manner Th1-type immune response in human peripheral blood mononuclear cells (PBMC) in vitro. Results show an anti-inflammatory property of compounds which however could shift the Th1-Th2-type immune balance towards Th2-type immunity.

MeSH terms

Cell Survival / drug effects
Cells, Cultured
Curcumin / pharmacology*
Food Coloring Agents / pharmacology*
Food Preservatives / pharmacology*
Humans
Immunosuppressive Agents*
In Vitro Techniques
Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism
Mitogens / pharmacology
Propionates / pharmacology*
Sodium Benzoate / pharmacology*
Th1 Cells / chemistry
Th1 Cells / drug effects*
Th1 Cells / immunology*

Substances

Food Coloring Agents
Food Preservatives
Immunosuppressive Agents
Indoleamine-Pyrrole 2,3,-Dioxygenase
Mitogens
Propionates
Curcumin
propionic acid
Sodium Benzoate