Abstract
Substitution of the fluoro or methoxy group in unprotected 2-fluoro- and 2-methoxybenzoic acids to afford N-aryl and N-alkyl anthranilic acids occurs upon reaction with lithioamides under mild conditions in the absence of a metal catalyst.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry*
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Benzoates / chemistry*
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Lithium / chemistry*
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Molecular Structure
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Organometallic Compounds / chemistry*
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Stereoisomerism
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ortho-Aminobenzoates / chemical synthesis*
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ortho-Aminobenzoates / chemistry
Substances
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Amides
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Benzoates
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Organometallic Compounds
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ortho-Aminobenzoates
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Lithium