Additional candidates to conventional genes susceptible for lung cancer and changing trend in Japan

Isao Okazaki; Minoru Sugita; Hideaki Matsuki; Syed Muhammad Baqui Billah; Tetsu Watanabe

doi:10.3892/or_00000788

Additional candidates to conventional genes susceptible for lung cancer and changing trend in Japan

Oncol Rep. 2010 Jun;23(6):1493-500. doi: 10.3892/or_00000788.

Authors

Isao Okazaki¹, Minoru Sugita, Hideaki Matsuki, Syed Muhammad Baqui Billah, Tetsu Watanabe

Affiliation

¹ Department of Internal Medicine, Sanno Hospital, International University of Health and Welfare, Tokyo 107-0052, Japan. iokazaki@iuhw.ac.jp

PMID: 20428802
DOI: 10.3892/or_00000788

Abstract

The polymorphism of CYP1A1*2A or CYP1A1*2B, and the linkage of CYP1A1*2A, CYP1A1*2B, GSTM1 and GSTT1 polymorphisms have been established as susceptible genes or gene-gene interactions of tobacco-related lung cancer. New candidate genes susceptible for lung cancer such as NQO1 (NAD(P)H:quinine oxidoreductase), NAT2 (N-acetyltransferase 2), and several others have been reported. In the present review we focus on new candidate genes susceptible for lung cancer, then examine all Japanese references by meta-analysis on susceptible genes over the past 20 years, and discuss whether new candidates and changing trend in Japan could be caused by environmental change.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Asian People / genetics*
Genetic Predisposition to Disease / ethnology*
Genetic Predisposition to Disease / genetics*
Humans
Lung Neoplasms / epidemiology
Lung Neoplasms / etiology*
Neoplasm Proteins / genetics*

Substances

Neoplasm Proteins