Ruthenium/TFA-catalyzed regioselective C-3-alkylation of indoles with terminal alkynes in water: efficient and unprecedented access to 3-(1-methylalkyl)-1H-indoles

Chem Commun (Camb). 2010 Jun 21;46(23):4175-7. doi: 10.1039/c002804e. Epub 2010 Apr 28.

Abstract

An unprecedented C-3-alkylation reaction of indoles with terminal alkynes in aqueous medium has been developed using catalytic amounts of ruthenium and trifluoroacetic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Alkynes / chemistry*
  • Catalysis
  • Indoles / chemistry*
  • Molecular Structure
  • Ruthenium / chemistry*
  • Stereoisomerism
  • Trifluoroacetic Acid / chemistry
  • Water / chemistry

Substances

  • Alkynes
  • Indoles
  • Water
  • Ruthenium
  • Trifluoroacetic Acid