Multifunctional polymeric nanoparticles for combined chemotherapeutic and near-infrared photothermal cancer therapy in vitro and in vivo

Chem Commun (Camb). 2010 May 14;46(18):3167-9. doi: 10.1039/b919172k. Epub 2010 Mar 15.

Abstract

Multifunctional Taxol-loaded PLGA nanoparticles show chemotherapeutic and photothermal destruction of cancer cells in vitro and in vivo.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Cell Line
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • HeLa Cells
  • Humans
  • Mice
  • Mice, SCID
  • Nanoparticles / chemistry*
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • Paclitaxel / administration & dosage*
  • Paclitaxel / therapeutic use
  • Phototherapy
  • Spectroscopy, Near-Infrared
  • Temperature

Substances

  • Antineoplastic Agents, Phytogenic
  • Paclitaxel