Abstract
We investigated the impact of probiotics on the intestinal carriage of vancomycin-resistant enterococci (VRE). Administration of Lactobacillus rhamnosus Lcr35 but not Escherichia coli Nissle reduced, although not significantly, the density of VRE colonization in a murine model. No effect of Lcr35 was observed in a double-blind placebo randomized study, involving nine patients.
Trial registration:
ClinicalTrials.gov NCT00437580.
Publication types
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Randomized Controlled Trial
MeSH terms
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Aged
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Aged, 80 and over
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Animals
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Carrier State* / microbiology
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Carrier State* / physiopathology
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Colony Count, Microbial
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Disease Models, Animal
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Double-Blind Method
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Electrophoresis, Agar Gel
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Enterococcus / drug effects*
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Escherichia coli
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Feces / microbiology
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Humans
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Lacticaseibacillus rhamnosus
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Mice
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Middle Aged
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Phylogeny
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Pilot Projects
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Probiotics / therapeutic use*
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Vancomycin Resistance / drug effects*
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Vancomycin* / adverse effects
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Vancomycin* / pharmacology
Associated data
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ClinicalTrials.gov/NCT00437580