Probiotics and intestinal colonization by vancomycin-resistant enterococci in mice and humans

J Clin Microbiol. 2010 Jul;48(7):2595-8. doi: 10.1128/JCM.00473-10. Epub 2010 Apr 26.

Abstract

We investigated the impact of probiotics on the intestinal carriage of vancomycin-resistant enterococci (VRE). Administration of Lactobacillus rhamnosus Lcr35 but not Escherichia coli Nissle reduced, although not significantly, the density of VRE colonization in a murine model. No effect of Lcr35 was observed in a double-blind placebo randomized study, involving nine patients.

Trial registration: ClinicalTrials.gov NCT00437580.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Animals
  • Carrier State* / microbiology
  • Carrier State* / physiopathology
  • Colony Count, Microbial
  • Disease Models, Animal
  • Double-Blind Method
  • Electrophoresis, Agar Gel
  • Enterococcus / drug effects*
  • Escherichia coli
  • Feces / microbiology
  • Humans
  • Lacticaseibacillus rhamnosus
  • Mice
  • Middle Aged
  • Phylogeny
  • Pilot Projects
  • Probiotics / therapeutic use*
  • Vancomycin Resistance / drug effects*
  • Vancomycin* / adverse effects
  • Vancomycin* / pharmacology

Substances

  • Vancomycin

Associated data

  • ClinicalTrials.gov/NCT00437580