Abstract
Arousal level and metabolic demand is minimal during sleep, increases during quiet wakefulness, and further increases during active wakefulness phenomena such as exercise, stress, or panic. We summarize here our recent finding and relevant evidence showing possible contribution of orexin, a hypothalamic neuropeptide, to the state-dependent adjustment of central cardiorespiratory regulation. Orexin neurons seem to be a pivotal link between conscious and unconscious brain functions.
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arousal / physiology*
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Autonomic Nervous System / metabolism
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Cardiovascular Physiological Phenomena* / drug effects
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Disease Models, Animal
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Humans
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Intracellular Signaling Peptides and Proteins / administration & dosage
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Intracellular Signaling Peptides and Proteins / deficiency
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Intracellular Signaling Peptides and Proteins / metabolism*
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Mice
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Neurons / drug effects
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Neurons / metabolism*
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Neuropeptides / administration & dosage
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Neuropeptides / deficiency
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Neuropeptides / metabolism*
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Orexins
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Respiratory Physiological Phenomena* / drug effects
Substances
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Intracellular Signaling Peptides and Proteins
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Neuropeptides
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Orexins