The aim of this study was to assess the reliability and validity of the Turkish version of the Quick Disability of the Arm, Shoulder, and Hand (Quick DASH) scale in patients with carpal tunnel syndrome (CTS). Sixty nine patients with idiopathic CTS were included. The Quick DASH questionnaire consists of three subscales including disability/symptom, and work and sports/performing arts. Quick DASH was administered after translation process to subjects twice a week for testing reliability. The validity was based on correlating Quick DASH with the Boston Questionnaire, visual analogue scale-pain (VAS-pain), and pinch and grip strength tests. Reliability of the Turkish version of the Quick DASH scale was very good with high internal consistency (Cronbach's alpha 0.84 for disability/symptom subscale, 0.937 for work subscale, and 0.926 for sports/performing arts subscale) and test-retest reliability (intraclass correlation coefficient 0.931 for disability/symptom subscale, 0.925 for work subscale, and 0.779 for sports/performing arts subscale). The disability/symptom subscale had moderate correlations with the VAS-pain and grip strength test and good correlation with the pinch strength test. The work subscales had moderate correlations with VAS-pain, and pinch and pinch grip strength tests. A high correlation was found between the disability/symptom and work subscales with Boston symptom severity and Boston functional status subscores. The Turkish version of Quick DASH was reliable and valid for evaluating symptoms and functional disability in patients with CTS. Our results suggest that Quick DASH could be preferred as it is a simple and easy scale to use.