Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo

Jinfeng Xing; Liandong Deng; Shutao Guo; Anjie Dong; Xing-Jie Liang

doi:10.2174/138955710791185127

Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo

Mini Rev Med Chem. 2010 Feb;10(2):126-37. doi: 10.2174/138955710791185127.

Authors

Jinfeng Xing¹, Liandong Deng, Shutao Guo, Anjie Dong, Xing-Jie Liang

Affiliation

¹ Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China. liangxj@nanoctr.cn

PMID: 20408797
DOI: 10.2174/138955710791185127

Abstract

Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA) in vivo.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Gene Transfer Techniques*
Genetic Therapy*
Nanoparticles / chemistry*
Oligonucleotides / chemistry
Oligonucleotides / pharmacology
Plasmids / chemistry
Plasmids / pharmacology
Polyamines / chemistry*
Polyamines / pharmacology
Polyelectrolytes

Substances

Oligonucleotides
Polyamines
Polyelectrolytes
polycations