Abstract
Frontotemporal dementia is the second most common early onset dementia after Alzheimer disease. Frontotemporal dementias are a complex group of dementias. The clinical diagnosis can be perplexing because of concurring psychiatric and neurologic syndromes. Frontotemporal lobar degeneration, the underlying pathology, represents an emerging group of proteinopathies. Genetic factors play an important part in the etiologies of dementias. This article overviews current defining characteristics of frontotemporal dementias known also as frontotemporal lobar degenerations.
MeSH terms
-
Adenosine Triphosphatases / genetics
-
Adenosine Triphosphatases / metabolism
-
Brain / metabolism*
-
Brain / pathology*
-
Cell Cycle Proteins / genetics
-
Cell Cycle Proteins / metabolism
-
Chromosomes, Human, Pair 17
-
Diagnosis, Differential
-
Frontotemporal Dementia / diagnosis*
-
Frontotemporal Dementia / genetics
-
Frontotemporal Dementia / metabolism
-
Frontotemporal Dementia / pathology
-
Frontotemporal Lobar Degeneration / diagnosis*
-
Frontotemporal Lobar Degeneration / genetics
-
Frontotemporal Lobar Degeneration / metabolism
-
Frontotemporal Lobar Degeneration / pathology
-
Humans
-
Intercellular Signaling Peptides and Proteins / genetics
-
Intercellular Signaling Peptides and Proteins / metabolism
-
Nerve Tissue Proteins / genetics*
-
Nerve Tissue Proteins / metabolism*
-
Pick Disease of the Brain / diagnosis
-
Progranulins
-
Ubiquitin / genetics
-
Ubiquitin / metabolism
-
Valosin Containing Protein
-
tau Proteins / genetics
-
tau Proteins / metabolism
Substances
-
Cell Cycle Proteins
-
GRN protein, human
-
Intercellular Signaling Peptides and Proteins
-
MAPT protein, human
-
Nerve Tissue Proteins
-
Progranulins
-
Ubiquitin
-
tau Proteins
-
Adenosine Triphosphatases
-
Valosin Containing Protein