Synthesis and preliminary biological screening of sterol analogues as new antifungal agents against plant pathogens

Fernando Alonso; Adriana M Cirigliano; Gabriela M Cabrera; Javier A Ramírez

doi:10.1016/j.steroids.2010.04.002

Synthesis and preliminary biological screening of sterol analogues as new antifungal agents against plant pathogens

Steroids. 2010 Oct;75(10):659-64. doi: 10.1016/j.steroids.2010.04.002. Epub 2010 May 5.

Authors

Fernando Alonso¹, Adriana M Cirigliano, Gabriela M Cabrera, Javier A Ramírez

Affiliation

¹ Departamento de Química Orgánica and UMYMFOR (CONICET - Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 3, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina.

PMID: 20399221
DOI: 10.1016/j.steroids.2010.04.002

Abstract

In this paper we report the synthesis of a new family of sterol analogues that have two amidic bonds on the side chain. These azasterols were obtained by a straightforward procedure including an Ugi condensation that allows the facile attachment of a polyfunctionalized side chain into the steroidal framework. Some of the new compounds showed an interesting inhibitory effect on the growth of two pathogenic fungi involved in plant diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Azasteroids / chemical synthesis
Azasteroids / chemistry
Azasteroids / pharmacology
Fusarium / drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure

Substances

Antifungal Agents
Azasteroids