Antiaggressive activity of antibodies to S-100 protein in ultralow doses

Bull Exp Biol Med. 2009 Sep;148(3):527-9. doi: 10.1007/s10517-010-0755-0.
[Article in English, Russian]

Abstract

Experiments on rats demonstrated antiaggressive activity of ultralow doses of antibodies to S-100 protein in tests of motivated and unmotivated aggression. The effect of ultralow doses of antibodies to S-100 protein in single and course treatment was not inferior to that of benzodiazepine anxiolytic diazepam.

MeSH terms

  • Aggression / drug effects*
  • Animals
  • Anti-Anxiety Agents / therapeutic use*
  • Antibodies / immunology*
  • Antibodies / therapeutic use*
  • Behavior, Animal / drug effects
  • Diazepam / therapeutic use*
  • Male
  • Rats
  • S100 Proteins / immunology*

Substances

  • Anti-Anxiety Agents
  • Antibodies
  • S100 Proteins
  • Diazepam