Vesicular traffic: a Rab SANDwich

Michal Bohdanowicz; Sergio Grinstein

doi:10.1016/j.cub.2010.02.030

Vesicular traffic: a Rab SANDwich

Curr Biol. 2010 Apr 13;20(7):R311-4. doi: 10.1016/j.cub.2010.02.030.

Authors

Michal Bohdanowicz¹, Sergio Grinstein

Affiliation

¹ Cell Biology Program, Hospital for Sick Children and Institute of Medical Science, University of Toronto, Toronto, Canada.

PMID: 20392419
DOI: 10.1016/j.cub.2010.02.030

Abstract

The small GTPases Rab5 and Rab7 mark temporally distinct but sequentially connected stages in phagosome maturation, but the mechanism underlying the transition between these stages has been unclear. Recent studies in Caenorhabditis elegans have now uncovered a new protein complex that connects Rab5 to Rab7.

MeSH terms

Animals
Caenorhabditis elegans / physiology
Caenorhabditis elegans Proteins / chemistry
Caenorhabditis elegans Proteins / physiology*
Cytoplasmic Vesicles / physiology
Models, Biological
Multiprotein Complexes
Phagocytosis / physiology
rab GTP-Binding Proteins / chemistry
rab GTP-Binding Proteins / physiology*
rab5 GTP-Binding Proteins / chemistry
rab5 GTP-Binding Proteins / physiology
rab7 GTP-Binding Proteins

Substances

Caenorhabditis elegans Proteins
Multiprotein Complexes
rab7 GTP-Binding Proteins
rab GTP-Binding Proteins
rab5 GTP-Binding Proteins