Two new xanthones from Artocarpus obtusus

Najihah Hashim; Mawardi Rahmani; Mohd A Sukari; Abdul M Ali; Noorjahan B Alitheen; Rosea Go; Hazar B M Ismail

doi:10.1080/10286020903450411

Two new xanthones from Artocarpus obtusus

J Asian Nat Prod Res. 2010 Feb;12(2):106-12. doi: 10.1080/10286020903450411.

Authors

Najihah Hashim¹, Mawardi Rahmani, Mohd A Sukari, Abdul M Ali, Noorjahan B Alitheen, Rosea Go, Hazar B M Ismail

Affiliation

¹ Department of Chemistry, Universiti Putra Malaysia 43400 UPM, Selangor, Malaysia.

PMID: 20390751
DOI: 10.1080/10286020903450411

Abstract

Two new xanthones, pyranocycloartobiloxanthone A (1) and dihydroartoindonesianin C (2), were isolated from the stem bark of Artocarpus obtusus Jarrett by chromatographic separation. Their structures were determined by using spectroscopic methods and comparison with known related compounds. Pyranocycloartobiloxanthone A (1) showed strong free radical scavenging activity by using DPPH assay as well as cytotoxicity towards K562, HL-60, and MCF7 cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Artocarpus / chemistry*
Biphenyl Compounds / pharmacology
Drug Screening Assays, Antitumor
Free Radical Scavengers / chemistry
Free Radical Scavengers / isolation & purification*
Free Radical Scavengers / pharmacology
Malaysia
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Picrates / pharmacology
Plant Bark / chemistry
Plants, Medicinal / chemistry*
Xanthones / chemistry
Xanthones / isolation & purification*
Xanthones / pharmacology

Substances

Biphenyl Compounds
Free Radical Scavengers
Picrates
Xanthones
dihydroartoindonesianin C
pyranocycloartobiloxanthone A
1,1-diphenyl-2-picrylhydrazyl