Deconstructing ERK signaling in tumorigenesis

Mol Cell. 2010 Apr 9;38(1):3-5. doi: 10.1016/j.molcel.2010.03.012.

Abstract

Ras proteins play important protumorigenic roles by activating multiple signaling pathways. A study in this issue of Molecular Cell (Shin et al., 2010) dissects the implications of ERK2 signaling downstream of oncogenic Ras in the induction of epithelial-to-mesenchymal transition (EMT), cell motility, and invasion.

Publication types

  • Comment

MeSH terms

  • Cell Differentiation / physiology
  • Cell Transformation, Neoplastic*
  • Enzyme Activation
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MAP Kinase Signaling System / physiology*
  • Mitogen-Activated Protein Kinase 1 / genetics
  • Mitogen-Activated Protein Kinase 1 / metabolism*
  • Mitogen-Activated Protein Kinase 3 / genetics
  • Mitogen-Activated Protein Kinase 3 / metabolism*
  • Neoplasms / metabolism*
  • Neoplasms / physiopathology
  • ras Proteins / genetics
  • ras Proteins / metabolism*

Substances

  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
  • ras Proteins