Bis-tetrahydroisoquinoline derivatives: structure analysis of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline)

Johan Wouters; Kossay Elasaad; Bernadette Norberg; Amaury Graulich; Jean-François Liégeois

doi:10.1016/j.ejmech.2010.03.020

Bis-tetrahydroisoquinoline derivatives: structure analysis of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline)

Eur J Med Chem. 2010 Jul;45(7):3240-4. doi: 10.1016/j.ejmech.2010.03.020. Epub 2010 Mar 25.

Authors

Johan Wouters¹, Kossay Elasaad, Bernadette Norberg, Amaury Graulich, Jean-François Liégeois

Affiliation

¹ Department of Chemistry, University of Namur, rue de Bruxelles, 61, B-5000 Namur, Belgium. johan.wouters@fundp.ac.be

PMID: 20381214
DOI: 10.1016/j.ejmech.2010.03.020

Abstract

Crystal structure of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Crystallography, X-Ray
Models, Molecular
Molecular Conformation
Stereoisomerism
Tetrahydroisoquinolines / chemical synthesis*
Tetrahydroisoquinolines / chemistry*

Substances

1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline)
Tetrahydroisoquinolines