Gastrin: an acid-releasing, proliferative and immunomodulatory peptide?

Mini Rev Med Chem. 2010 Jan;10(1):8-19. doi: 10.2174/138955710791112532.

Abstract

Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Proliferation*
  • Gastric Acid / metabolism*
  • Gastrin-Secreting Cells / drug effects
  • Gastrin-Secreting Cells / physiology
  • Gastrinoma / physiopathology
  • Gastrins / genetics
  • Gastrins / metabolism
  • Gastrins / physiology*
  • Gastritis / physiopathology
  • Humans
  • Immunomodulation*
  • Protein Precursors / genetics
  • Protein Precursors / metabolism
  • Receptors, Cholecystokinin / antagonists & inhibitors
  • Receptors, Cholecystokinin / physiology
  • Signal Transduction

Substances

  • Gastrins
  • Protein Precursors
  • Receptors, Cholecystokinin
  • preprogastrin