Abstract
Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Proliferation*
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Gastric Acid / metabolism*
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Gastrin-Secreting Cells / drug effects
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Gastrin-Secreting Cells / physiology
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Gastrinoma / physiopathology
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Gastrins / genetics
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Gastrins / metabolism
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Gastrins / physiology*
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Gastritis / physiopathology
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Humans
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Immunomodulation*
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Protein Precursors / genetics
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Protein Precursors / metabolism
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Receptors, Cholecystokinin / antagonists & inhibitors
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Receptors, Cholecystokinin / physiology
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Signal Transduction
Substances
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Gastrins
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Protein Precursors
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Receptors, Cholecystokinin
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preprogastrin