Lyme disease is a multisystem infectious disease with a wide variety of symptoms involving the skin as well as the nervous system. Lyme disease is caused by spirochaete Borrelia burgdorferi transmitted by Ixodes ticks in endemic regions. A case of 45 year old woman suffering from borreliosis, psoriasis and depression is presented in the paper. In the study a standardized screening list was applied to evaluate the psychiatric health state--Classification of Psychic Disorders (DSM-IV) and Hamilton Scale. Patient was diagnosed with a major depressive episode (MDE) according to DSM-IV Diagnosis Criteria. Patient obtained a score 21 on the 24-item in Hamilton Rating Scale of Depression. Primary manifestation of boreliosis in patient with psoriasis increase a risk of depression.