The effect of gas compression on spontaneous flame acceleration leading to deflagration-to-detonation transition is studied theoretically for small Reynolds number flame propagation from the closed end of a tube. The theory assumes weak compressibility through expansion in small Mach number. Results show that the flame front accelerates exponentially during the initial stage of propagation when the Mach number is negligible. With continuous increase in the flame velocity with respect to the tube wall, the flame-generated compression waves subsequently moderate the acceleration process by affecting the flame shape and velocity, as well as the flow driven by the flame.