Abstract
Background:
Nanotechnology is rapidly emerging in biomedical applications, including cancer therapy. Here, a mixture of ultra dispersed nanodiamond and nanoplatinum was coated onto fabrics in the form of a cloth (DPV576-C). The role of DPV576-C in modulating T lymphocytes of aged mice was examined.
Materials and methods:
C57BL/6 mice were treated with DPV576-C as a lining in a mouse house for 1 month. Splenic cells were analyzed for CD4(+) and CD8(+) T-cells and NK activity using flow cytometry.
Results:
DPV576-C-treated aged mice showed an: (1) increase in the percentages of CD4(+) and CD8(+) T-cells and their activation markers, CD25 and CD69, over untreated aged mice; (2) enhancement of NK activity; and (3) absence of adverse side effects as determined histopathologically.
Conclusion:
The enhancement of lymphocytes by DPV576-C may be useful for patients suffering from immune dysfunction.
MeSH terms
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Animals
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Antigens, CD / metabolism
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Antigens, Differentiation, T-Lymphocyte / metabolism
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CD4-Positive T-Lymphocytes / cytology
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / metabolism
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CD8-Positive T-Lymphocytes / cytology
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CD8-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / metabolism
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Cellular Senescence / immunology*
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Coated Materials, Biocompatible*
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Diamond
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Female
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Flow Cytometry
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Housing, Animal
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Immune System Diseases / immunology
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Immune System Diseases / therapy*
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Interleukin-2 Receptor alpha Subunit / metabolism
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Killer Cells, Natural / cytology
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Killer Cells, Natural / immunology
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Killer Cells, Natural / metabolism
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Lectins, C-Type / metabolism
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Lymphocyte Activation / immunology
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Mice
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Mice, Inbred C57BL
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Nanofibers*
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Platinum
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
Substances
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Antigens, CD
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Antigens, Differentiation, T-Lymphocyte
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CD69 antigen
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Coated Materials, Biocompatible
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Il2ra protein, mouse
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Interleukin-2 Receptor alpha Subunit
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Lectins, C-Type
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Platinum
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Diamond