Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora

Chavi Yenjai; Suchana Wanich

doi:10.1016/j.bmcl.2010.03.054

Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora

Bioorg Med Chem Lett. 2010 May 1;20(9):2821-3. doi: 10.1016/j.bmcl.2010.03.054. Epub 2010 Mar 15.

Authors

Chavi Yenjai¹, Suchana Wanich

Affiliation

¹ Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. chayen@kku.ac.th

PMID: 20362442
DOI: 10.1016/j.bmcl.2010.03.054

Abstract

Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC(50) values of 0.014 and 0.23 microM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC(50) values of 4.04 and 2.32 microM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Antineoplastic Agents / toxicity
Benzopyrans / chemical synthesis
Benzopyrans / chemistry*
Benzopyrans / toxicity
Cell Line, Tumor
Flavonoids / chemical synthesis
Flavonoids / chemistry*
Flavonoids / toxicity
Humans
Oximes / chemical synthesis
Oximes / chemistry*
Oximes / toxicity
Zingiberaceae / chemistry*

Substances

Antineoplastic Agents
Benzopyrans
Flavonoids
Oximes