Desulfitative cross-coupling of protecting group-free 2-thiouracil derivatives with organostannanes

Qi Sun; Franck Suzenet; Gérald Guillaumet

doi:10.1021/jo1003482

Desulfitative cross-coupling of protecting group-free 2-thiouracil derivatives with organostannanes

J Org Chem. 2010 May 21;75(10):3473-6. doi: 10.1021/jo1003482.

Authors

Qi Sun¹, Franck Suzenet, Gérald Guillaumet

Affiliation

¹ School of Pharmaceutical Science, Peking University, 38, Xueyuan Road, Haidian District, Beijing, China, 100191.

PMID: 20359202
DOI: 10.1021/jo1003482

Abstract

We here report a unique and efficient copper bromide mediated pallado-catalyzed coupling of protecting group-free 2-thiouracil derivatives with organostannanes. The nature of the copper appears to be crucial for successful cross coupling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Copper / chemistry
Molecular Structure
Organotin Compounds / chemistry*
Palladium / chemistry
Stereoisomerism
Thiouracil / chemistry*

Substances

Organotin Compounds
Thiouracil
Palladium
Copper