Tuberculous orchiepididymitis during 1978-2003 period: review of 34 cases and role of 16S rRNA amplification

Urology. 2010 Oct;76(4):776-81. doi: 10.1016/j.urology.2010.01.033. Epub 2010 Mar 29.

Abstract

Genitourinary tuberculosis was diagnosed in 543 patients in Spanish hospital from 1978 through 2003. Of the 371 male 34 (9.2%) had orchiepididymitis. Mean age was 52.7 years and the presenting symptom was scrotal swelling and/or pain. Over 50% of cases involved the right ovotestis. Associated renal tuberculosis and active disease in extraurological organs presented in 64% and 19.2% of cases, respectively. Diagnosis was established by culture of Mycobacterium tuberculosis recovery from urine and/or purulent scrotal exudate. Genomic amplification techniques aided the diagnosis in 8 patients. Treatment was rifampin, isoniazide, and pyrazinamide or ethambutol. Eight patients required combined medical and surgical treatment.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antitubercular Agents / therapeutic use
  • Combined Modality Therapy
  • Comorbidity
  • Epididymitis / diagnosis
  • Epididymitis / drug therapy
  • Epididymitis / epidemiology*
  • Epididymitis / microbiology
  • Epididymitis / surgery
  • Ethambutol / therapeutic use
  • Exudates and Transudates / microbiology
  • HIV Infections / epidemiology
  • Humans
  • Isoniazid / therapeutic use
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis / classification
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / isolation & purification*
  • Orchitis / diagnosis
  • Orchitis / drug therapy
  • Orchitis / epidemiology*
  • Orchitis / microbiology
  • Orchitis / surgery
  • Prostatitis / drug therapy
  • Prostatitis / epidemiology
  • Prostatitis / microbiology
  • Pyrazinamide / therapeutic use
  • RNA, Ribosomal, 16S / genetics*
  • Retrospective Studies
  • Ribotyping*
  • Rifampin / therapeutic use
  • Scrotum / microbiology
  • Spain / epidemiology
  • Tuberculosis, Male Genital / diagnosis
  • Tuberculosis, Male Genital / drug therapy
  • Tuberculosis, Male Genital / epidemiology*
  • Tuberculosis, Male Genital / microbiology
  • Tuberculosis, Male Genital / surgery
  • Tuberculosis, Renal / epidemiology
  • Urine / microbiology

Substances

  • Antitubercular Agents
  • RNA, Ribosomal, 16S
  • Pyrazinamide
  • Ethambutol
  • Isoniazid
  • Rifampin