Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2461-4. doi: 10.1016/j.bmcl.2010.03.013. Epub 2010 Mar 7.

Abstract

A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 microM. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Biofilms*
  • Drug Design*
  • Staphylococcus epidermidis / drug effects
  • Thiazoles / chemical synthesis
  • Thiazoles / chemistry*
  • Thiazoles / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Thiazoles