Opening the TRPML gates

Soichiro Yamaguchi; Shmuel Muallem

doi:10.1016/j.chembiol.2010.02.009

Opening the TRPML gates

Chem Biol. 2010 Mar 26;17(3):209-10. doi: 10.1016/j.chembiol.2010.02.009.

Authors

Soichiro Yamaguchi¹, Shmuel Muallem

Affiliation

¹ Department of Physiology, University of Texas, Southwestern Medical center, Dallas, TX 75390, USA.

Abstract

The intracellular TRPML channels have multiple biological roles, but the physiological stimuli that open them remained unknown. In a previous issue of Chemistry & Biology, Grimm et al. report a high-throughput chemical screen that identified a plethora of selective activators of TRPML3 that should open the way to fully characterize these channels and their physiological roles.

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