Abstract
An amphotericin B derivative exhibits differential interaction with vesicles formed from either natural (R)-or unnatural (S)-POPC and ergosterol. This implicates a close association between the polyene macrolide and the phospholipid bilayer and may account for its increased antifungal activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / analogs & derivatives*
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Amphotericin B / metabolism*
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Cell Membrane / chemistry*
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Cell Membrane / metabolism*
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Ergosterol / metabolism*
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Phospholipids / chemistry
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Potassium / metabolism
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Stereoisomerism
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Substrate Specificity
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Unilamellar Liposomes / chemistry
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Unilamellar Liposomes / metabolism
Substances
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Phospholipids
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Unilamellar Liposomes
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Amphotericin B
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Potassium
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Ergosterol