Design, synthesis and anti-HIV integrase evaluation of N-(5-chloro-8-hydroxy-2-styrylquinolin-7-yl)benzenesulfonamide derivatives

Zi-Guo Jiao; Hong-Qiu He; Cheng-Chu Zeng; Jian-Jun Tan; Li-Ming Hu; Cun-Xin Wang

doi:10.3390/molecules15031903

Design, synthesis and anti-HIV integrase evaluation of N-(5-chloro-8-hydroxy-2-styrylquinolin-7-yl)benzenesulfonamide derivatives

Molecules. 2010 Mar 16;15(3):1903-17. doi: 10.3390/molecules15031903.

Authors

Zi-Guo Jiao¹, Hong-Qiu He, Cheng-Chu Zeng, Jian-Jun Tan, Li-Ming Hu, Cun-Xin Wang

Affiliation

¹ College of Life Science & Bioengineering, Beijing University of Technology, Beijing, China. jiaoziguo@emails.bjut.edu.cn

Abstract

Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized,and their possible HIV IN inhibitory activity was evaluated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Evaluation, Preclinical
HIV Integrase Inhibitors / chemical synthesis*
HIV Integrase Inhibitors / chemistry
HIV Integrase Inhibitors / pharmacology*
Magnetic Resonance Spectroscopy
Spectrometry, Mass, Electrospray Ionization
Sulfonamides / chemical synthesis*
Sulfonamides / chemistry
Sulfonamides / pharmacology*

Substances

HIV Integrase Inhibitors
Sulfonamides