Estrogen receptor ESR1 controls cell migration by repressing chemokine receptor CXCR4 in the zebrafish posterior lateral line system

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6358-63. doi: 10.1073/pnas.0909998107. Epub 2010 Mar 22.

Abstract

The primordium that generates the embryonic posterior lateral line of zebrafish migrates from the head to the tip of the tail along a trail of SDF1-producing cells. This migration critically depends on the presence of the SDF1 receptor CXCR4 in the leading region of the primordium and on the presence of a second SDF1 receptor, CXCR7, in the trailing region of the primordium. Here we show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression, suggesting that ESR1 acts as a repressor of cxcr4b. This finding could explain why estrogens significantly decrease the metastatic ability of ESR-positive breast cancer cells. ESR1 inactivation also leads to extinction of cxcr7b expression in the trailing cells of the migrating primordium; this effect is indirect, however, and due to the down-regulation of cxcr7b by ectopic SDF1/CXCR4 signaling in the trailing region. Both ESR1 inactivation and overexpression result in aborted migration, confirming the importance of this receptor in the control of SDF1-dependent migration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cell Movement*
  • Estrogen Receptor alpha / genetics
  • Estrogen Receptor alpha / metabolism*
  • Gene Expression Regulation, Developmental
  • Lateral Line System / embryology*
  • Lateral Line System / metabolism*
  • Molecular Sequence Data
  • Receptors, CXCR / genetics
  • Receptors, CXCR / metabolism
  • Receptors, CXCR4 / genetics
  • Receptors, CXCR4 / metabolism*
  • Signal Transduction
  • Zebrafish / embryology*
  • Zebrafish / genetics
  • Zebrafish / metabolism*
  • Zebrafish Proteins / genetics
  • Zebrafish Proteins / metabolism*

Substances

  • CXCR4b protein, zebrafish
  • CXCR7 protein, zebrafish
  • Estrogen Receptor alpha
  • Receptors, CXCR
  • Receptors, CXCR4
  • Zebrafish Proteins

Associated data

  • GENBANK/GU394077
  • GENBANK/GU394078
  • GENBANK/GU394079
  • GENBANK/GU394080
  • GENBANK/GU394081