Synthesis of fluorene and indenofluorene compounds: tandem palladium-catalyzed suzuki cross-coupling and cyclization

Abstract

"Fluor" it: palladium-catalyzed tandem reactions, in which C(sp(3))-H bond activation is the key step (see scheme; DMA=dimethylacetamide), lead to substituted fluorenes and indenofluorenes through annulation in high yield and in one step. This method has potential for the preparation of other cyclic compounds, as well as substituted oligofluorenes and polyfluorenes.