Abstract
Malignant gliomas, despite aggressive multimodal therapies and adequate supportive care, still maintain poor prognosis. Solid lipid nanoparticles (SLN) are colloidal carriers that could be regarded as a highly flexible platform for brain tumor imaging and therapeutical purposes. In this chapter we will first describe brain tumors characteristics and conventional therapeutical approaches. In the subsequent sections, we will analyze SLN properties, effectiveness, and future perspectives in both imaging and targeted treatment of malignant gliomas.
Copyright 2009 Elsevier B.V. All rights reserved.
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / pharmacokinetics
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Blood-Brain Barrier / drug effects
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Blood-Brain Barrier / metabolism
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Brain Neoplasms / drug therapy*
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Disease Models, Animal
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Humans
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Lipids / chemical synthesis
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Lipids / pharmacokinetics*
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Medical Oncology / methods
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Nanoparticles / chemistry
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Nanoparticles / therapeutic use*
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Nanoparticles / toxicity
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Nanotechnology / methods*
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Nanotechnology / trends
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Neurochemistry / methods
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Neurochemistry / trends
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Neuropharmacology / methods*
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Neuropharmacology / trends
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Rats
Substances
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Antineoplastic Agents
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Lipids