S-acylation by the DHHC protein family

Biochem Soc Trans. 2010 Apr;38(2):522-4. doi: 10.1042/BST0380522.

Abstract

A family of 23 DHHC (Asp-His-His-Cys) proteins that function as mammalian S-acyltransferases has been identified, reinvigorating the study of protein S-acylation. Recent studies have continued to reveal how S-acylation affects target proteins, and have provided glimpses of how DHHC-substrate specificity might be achieved.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acylation
  • Acyltransferases / genetics
  • Acyltransferases / metabolism*
  • Acyltransferases / physiology
  • Animals
  • Catalysis
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Multigene Family
  • Proteins / metabolism
  • Substrate Specificity
  • Tissue Distribution

Substances

  • Membrane Proteins
  • Proteins
  • Acyltransferases