Abstract
Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Aging / drug effects*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology
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Antimutagenic Agents / chemistry
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Antimutagenic Agents / pharmacology*
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Cardiotonic Agents / chemistry
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Cardiotonic Agents / pharmacology
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Chemoprevention
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Flavonoids / chemistry
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Flavonoids / pharmacology
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Heart / drug effects*
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Humans
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Longevity / drug effects*
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Phenols / chemistry
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Phenols / pharmacology
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / pharmacology
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Polyphenols
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Resveratrol
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Stilbenes / chemistry
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Stilbenes / pharmacology*
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Wine*
Substances
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Anti-Inflammatory Agents
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Antimutagenic Agents
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Antioxidants
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Cardiotonic Agents
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Flavonoids
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Phenols
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Platelet Aggregation Inhibitors
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Polyphenols
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Stilbenes
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Resveratrol