Abstract
Mycobacterium tuberculosis (M.Tb) is a bacillus capable of causing a chronic and fatal condition in humans known as tuberculosis (TB). It is estimated that there are 8 million new cases of TB per year and 3.1 million infected people die annually. Thirty-six new amide quinoxaline 1,4-di-N-oxide derivatives have been synthesized and evaluated as potential anti-tubercular agents, obtaining biological values similar to the reference compound, Rifampin (RIF).
Copyright 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antitubercular Agents / chemical synthesis*
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Antitubercular Agents / pharmacology*
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Chlorocebus aethiops
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Chromatography, Thin Layer
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / growth & development
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Quinoxalines / chemical synthesis*
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Quinoxalines / pharmacology*
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Structure-Activity Relationship
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Tuberculosis / epidemiology
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Vero Cells
Substances
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Antitubercular Agents
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Indicators and Reagents
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Quinoxalines