Peripartum metabolic control in gestational diabetes

Am J Obstet Gynecol. 2010 Jun;202(6):568.e1-6. doi: 10.1016/j.ajog.2010.01.064. Epub 2010 Mar 15.

Abstract

Objective: We sought to evaluate intrapartum metabolic control in gestational diabetes mellitus (GDM) patients and maternal factors influencing intrapartum glycemic control and neonatal hypoglycemia risk.

Study design: A prospective observational study included 129 women with GDM admitted for delivery. Data collected included maternal intrapartum capillary blood glucose (CBG) and ketonemia, use of insulin, and neonatal hypoglycemia.

Results: In all, 86% of maternal intrapartum CBG values fell within target range (3.3-7.2 mmol/L) without need for insulin use. There were no cases of maternal hypoglycemia or severe ketosis. Intrapartum CBG >7.2 mmol/L was associated with third-trimester glycated hemoglobin (P = .02) and lack of endocrinologic follow-up (P = .04). Risk of neonatal hypoglycemia was related with pregnancy insulin use compared with dietary control (60.5% vs 29.5%; P = .02).

Conclusion: Peripartum metabolic control in GDM patients was achieved without insulin in most cases. Intrapartum glycemic control was related with third-trimester glycated hemoglobin and with no endocrinologic follow-up. Neonatal hypoglycemia was associated with insulin use during pregnancy.

MeSH terms

  • Adult
  • Blood Glucose / metabolism*
  • Delivery, Obstetric*
  • Diabetes, Gestational / drug therapy
  • Diabetes, Gestational / metabolism*
  • Female
  • Humans
  • Hypoglycemia / chemically induced
  • Hypoglycemia / metabolism
  • Hypoglycemic Agents / therapeutic use
  • Infant, Newborn
  • Insulin / therapeutic use
  • Maternal-Fetal Exchange
  • Pregnancy
  • Prospective Studies

Substances

  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin