Abstract
Four new sesquiterpenoid arenarone derivatives, 18-aminoarenarone (1), 19-aminoarenarone (2), 18-methylaminoarenarone (3), and 19-methylaminoarenarone (4), and the new dimeric popolohuanone F (5), a derivative of 19-aminoarenarone (2) and arenarol (6), have been isolated from the Australian marine sponge Dysidea sp. together with the known compounds arenarol (6) and popolohuanone A (7). The structures of the new compounds 1-5 were established from extensive NMR spectroscopic data. Popolohuanones A (7) and F (5) and arenarol (6) showed DPPH radical scavenging activity with IC(50) values of 35, 35, and 19 microM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Australia
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Biphenyl Compounds / pharmacology
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Dysidea / chemistry*
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification*
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Free Radical Scavengers / pharmacology
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Inhibitory Concentration 50
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Marine Biology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Picrates / pharmacology
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Quinones / chemistry
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Quinones / isolation & purification*
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Quinones / pharmacology
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
Substances
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Biphenyl Compounds
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Free Radical Scavengers
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Picrates
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Quinones
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Sesquiterpenes
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1,1-diphenyl-2-picrylhydrazyl