Production of 4-hydroxyphenyllactic acid by Lactobacillus sp. SK007 fermentation

J Biosci Bioeng. 2010 Apr;109(4):369-71. doi: 10.1016/j.jbiosc.2009.10.005. Epub 2009 Nov 22.

Abstract

The production of 4-hydroxyphenyllactic acid (4-HO-PLA), a novel antifungal compound, was studied in Lactobacillus sp. SK007 growth. When grown in MRS broth, the strain could produce 75 microg/ml HO-4-PLA, which was the highest reported so far. Tyrosine and 4-hydroxyphenylpyruvic acid (HO-4-PPA) supplements during fermentation could both increase the HO-4-PLA production yield, and the effect of HO-4-PPA on HO-4-PLA production was remarkably better than that of tyrosine. Using HO-4-PPA as substrate could effectively produce HO-4-PLA, which reached 1.26 mg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / metabolism*
  • Fermentation
  • Food Microbiology
  • Kinetics
  • Lactobacillus / drug effects
  • Lactobacillus / growth & development
  • Lactobacillus / metabolism*
  • Phenylpropionates / metabolism*
  • Phenylpyruvic Acids / metabolism
  • Phenylpyruvic Acids / pharmacology
  • Tyrosine / metabolism
  • Tyrosine / pharmacology

Substances

  • Antifungal Agents
  • Phenylpropionates
  • Phenylpyruvic Acids
  • 4-hydroxyphenylpyruvic acid
  • 4-hydroxyphenyllactic acid
  • Tyrosine