Kikuchi Fujimoto disease associated with cryptogenic organizing pneumonia: case report and literature review

BMC Infect Dis. 2010 Mar 11:10:64. doi: 10.1186/1471-2334-10-64.

Abstract

Background: The association of Kikuchi Fujimoto disease (KFD) with cryptogenic organizing pneumonia (COP) is extremely rare. We report a case of simultaneous diagnosis of KFD and COP.

Case presentation: A 33-year-old male presented with a 1-month cough illness and fever lasting for 5 days. The chest radiograph revealed double lower lobe infiltrate, which was unresponsive to antibiotics. A cervical lymph node was first found in the development of this disease. Bronchoscopy, bronchoalveolar lavage and lung biopsy established the diagnosis of COP, while a lymph node biopsy was consistent with KFD. The patient improved on steroids.

Conclusions: KFD and COP are possible part of a disease continuum, rather than separate entities.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / therapeutic use
  • Biopsy
  • Bronchoalveolar Lavage Fluid
  • Bronchoscopy
  • Cryptogenic Organizing Pneumonia / complications*
  • Cryptogenic Organizing Pneumonia / diagnosis*
  • Cryptogenic Organizing Pneumonia / drug therapy
  • Cryptogenic Organizing Pneumonia / pathology
  • Histiocytic Necrotizing Lymphadenitis / complications*
  • Histiocytic Necrotizing Lymphadenitis / diagnosis*
  • Histiocytic Necrotizing Lymphadenitis / drug therapy
  • Histiocytic Necrotizing Lymphadenitis / pathology
  • Humans
  • Lung / pathology
  • Lymph Nodes / pathology
  • Male
  • Radiography, Thoracic
  • Steroids / therapeutic use
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Steroids