Skeletal muscle damage frequently occurs after eccentric exercise, however, the relationship between intraindividual variability of eccentric exercise and skeletal muscle damage is not clear yet. The aim of the study was to test the hypothesis that prolonged decrease in skeletal muscle force depends on intraindividual variability of eccentric exercise. Eleven healthy men were asked to perform knee eccentric extension of 10 series with 12 repetitions (EE) with maximal intensity at 160 degrees/s. The maximal voluntary knee extension isometric torque (MVC) of the quadriceps muscle and isokinetic concentric torque (IT) at 30 degrees/s of knee angles were established before and 2 min, 60 min, 24 h and 14 days after EE. At 24 h and 48 h after EE muscle soreness and creatine kinase activity before and at 48 h after EE were calculated. The intraindividual variability of EE and autocorrelation coefficient of EE were calculated. We observed a significant decrease in MVC and IT after EE. The maximal isokinetic torque shifted to longer muscle length after EE. It was concluded that longer lasting (within 14 days) indirect symptoms of exercise induced muscle damage (decrease in muscle force) are closely related to variability of EE.