Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells

J Biomater Appl. 2011 May;25(8):877-93. doi: 10.1177/0885328210362125. Epub 2010 Mar 10.

Abstract

This study investigated the use of a Ti-containing quaternary phosphate glass system P(2)O(5)-Na(2)O-CaO-TiO(2) as a vehicle for strontium ion delivery to cells. Four glass compositions were manufactured: 0.5P(2)O(5)-0.15Na(2)O-0.05TiO(2)-(0.3 - x)CaO-xSrO (x = 0, 0.01, 0.03, and 0.05). Structural characterization revealed that sodium calcium phosphate is the dominant phase in all the glasses. Degradation studies demonstrated highly linear glass degradation, with Sr-containing glasses degrading at higher rates than the Sr-free glass. Biocompatibility studies using MG63 cells showed that the Sr-containing glasses possess excellent cell attachment and growth, particularly over short periods (~4 days).

MeSH terms

  • Biocompatible Materials / chemistry*
  • Cell Adhesion
  • Cell Line
  • Cell Proliferation
  • Drug Carriers / chemistry*
  • Glass / chemistry*
  • Humans
  • Ions / chemistry
  • Materials Testing
  • Oxides / chemistry
  • Pharmaceutical Vehicles / chemistry*
  • Strontium / administration & dosage*
  • Strontium / chemistry*
  • Surface Properties
  • Titanium / chemistry*
  • X-Ray Diffraction / methods

Substances

  • Biocompatible Materials
  • Drug Carriers
  • Ions
  • Oxides
  • Pharmaceutical Vehicles
  • sodium oxide-calcium oxide-diphosphorus pentoxide glass
  • titanium dioxide
  • Titanium
  • Strontium