MicroRNAs--targeting and target prediction

Takaya Saito; Pal Saetrom

doi:10.1016/j.nbt.2010.02.016

MicroRNAs--targeting and target prediction

N Biotechnol. 2010 Jul 31;27(3):243-9. doi: 10.1016/j.nbt.2010.02.016. Epub 2010 Feb 26.

Authors

Takaya Saito¹, Pal Saetrom

Affiliation

¹ Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.

PMID: 20219708
DOI: 10.1016/j.nbt.2010.02.016

Abstract

MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate many genes by base pairing to sites in mRNAs. The functionality of miRNAs overlaps that of short interfering RNAs (siRNAs), and many features of miRNA targeting have been revealed experimentally by studying miRNA-mimicking siRNAs. This review outlines the features associated with animal miRNA targeting and describes currently available prediction tools.

Publication types

Review

MeSH terms

3' Untranslated Regions
Animals
Base Sequence
Gene Targeting*
Humans
MicroRNAs / genetics*
MicroRNAs / metabolism
RNA, Small Interfering / genetics
RNA, Small Interfering / metabolism

Substances

3' Untranslated Regions
MicroRNAs
RNA, Small Interfering