Because of its unapparent infection and viral diversity, poliomyelitis is difficult infectious diseases to control globally. Nevertheless, effective vaccinations, global surveillance network, development of accurate viral diagnosis prompted the historical challenge, global polio eradication initiative (GPEI). Wild polio viruses are now confined in four countries, Nigeria, India, Pakistan and Afghanistan. However, at the very end stage of this program, it has been stagnated because of various reasons. From this, we can learn good lessons to control other infectious diseases including measles, influenza and etc. To share the passion to eradicate miserable infectious disease, poliomyelitis is the key.