Abstract
A novel poly(sodium methacrylate, methylmethacrylate) hydrophilic pressure sensitive adhesive (PSA) containing a large amount of water was designed. The effects of PEG400, glycerin, sorbitol, and/or NaCl on the in vitro and in vivo adhesive properties were investigated by means of a 2(4) full factorial design. The optimized formulation, containing all independent variables at the highest value, was loaded with lidocaine hydrochloride (LH). This formulation permitted to obtain a 4-fold higher LH flux through human skin with respect to the marketed products.
MeSH terms
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Adhesiveness
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Adhesives
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Administration, Cutaneous*
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Adult
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Anesthetics, Local / administration & dosage
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Anesthetics, Local / chemistry
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Biopharmaceutics
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Chemistry, Pharmaceutical
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Chromatography, High Pressure Liquid
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Drug Delivery Systems
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Erythema / chemically induced
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Excipients
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Glycerol / chemistry
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Humans
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Lidocaine / administration & dosage
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Lidocaine / chemistry
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Plasticizers
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Polymethyl Methacrylate / adverse effects
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Polymethyl Methacrylate / chemistry*
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Skin Absorption
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Sodium Chloride / chemistry
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Sorbitol / chemistry
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Spectrophotometry, Ultraviolet
Substances
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Adhesives
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Anesthetics, Local
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Excipients
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Plasticizers
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Sodium Chloride
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Sorbitol
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Polymethyl Methacrylate
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Lidocaine
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Glycerol